Pharmacological inhibition of ictal and interictal epileptiform discharges

Background: Epilepsy is a brain disorder characterized by an enduring predisposition to generate epileptic seizures. Seizures are transient occurrence of signs and/or symptoms due abnormal excessive and synchronous neuronal activity in the brain. Electroencephalogram (EEG), non-invasive instrumental test, has important role diagnosis epilepsy, as well monitoring results long-term treatment because it can detect interictal ictal discharges that crucial for confirmation classification Antiepileptic drugs first option patients with although effectiveness such limited only symptom control requires regular intaking patient. These exploit cell membrane channels, modifying their permeability, allowing either increase inhibitory neurotransmission or reduction excitatory one, hyperpolarizing neurons avoiding recurrence seizures without reversing stopping underlying mechanism epileptogenesis. Materials Methods: The internship took place Neurophysiopathology department Antonio, Biagio Cesare Arrigo’s hospital Alessandria, from October 2022 March 2023. During this period, was possible attend emergency prolonged recurrent during EEGrafic recording consequential amendments induced administration antiepileptic drugs. Follow up EEG also performed investigate modifications after period patient who been analyzed paper, underwent recordings obtained using bridge electrodes placed on scalp according international 10-20 system. Objectives: aim study analyze mechanisms action main drugs, relation physiological cellular regulating excitability effect epileptiform recordings.